Exploration into conolidine has brought about discovery of an opioid receptor in the body termed ACKR3/CXCR7. ACKR3 is apparently the most wanted target for conolidine, which also disregards one other 4 classical opioid receptors(three). Conolidine is found in the tabernaemontana divaricata plant, which can be during the Apocynaceae relatives. https://emiliokfwnc.blogofoto.com/69299754/a-review-of-alternative-natural-pain-relief-to-replace-traditional-painkillers