In the LSD-certain crystal structure, the side chain from the lid residue L209EL2 forms considerable hydrophobic contacts with both LSD and encompassing residues in TMs III, IV, and V (Figure 4C). In the event the lid moved apart to expose the binding pocket in simulation, several of these contacts broke. https://knoxupgyo.onesmablog.com/the-greatest-guide-to-limited-edition-exclusive-lsd-crystal-75808654