An extensive literature review of research in between 1995 and 2018 was performed using the Digital databases PubMed and EBSCO Host. Lookups were being done working with the next conditions: full knee arthroplasty (TKA); cyclooxygenase-two inhibitors; bracing; physical therapy; fat loss; knee; treatment; therapeutics; OA; intra-articular injection; hyaluronic acid; corticosteroid; https://www.theorthopaedicandpainpractice.com/non-surgical-treatments-for-knee-joint-pain/