The impairment of HMGB1 function leads to elevated mitochondrial DNA damage. Within the SCA1 mouse product, around-expression from the HMGB1 protein by way of an introduced virus vector bearing the HMGB1 gene facilitates restore in the mitochondrial DNA injury, ameliorates the neuropathology and the motor deficits, and extends the lifespan https://miltonj776iwg4.wikijm.com/user